Point mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling

Mutations in the Nkx2-5 gene are a main cause of congenital heart disease. Several studies have addressed the phenotypic consequences of disrupting the Nkx2-5 gene locus, although animal models to date failed to recapitulate the full spectrum of the human disease. Here, we describe a new Nkx2-5 poin...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Furtado, Milena B., Wilmanns, Julia C., Chandran, Anjana, Perera, Joelle, Hon, Olivia, Biben, Christine, Willow, Taylor J., Nim, Hieu T., Kaur, Gurpreet, Simonds, Stephanie, Wu, Qizhu, Willians, David, Salimova, Ekaterina, Plachta, Nicolas, Denegre, James M., Murray, Stephen A., Fatkin, Diane, Cowley, Michael, Pearson, James T., Kaye, David, Ramialison, Mirana, Harvey, Richard P., Rosenthal, Nadia A., Costa, Mauro W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358496/
https://ncbi.nlm.nih.gov/pubmed/28352650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88271
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados