LRRK2 but not ATG16L1 is associated with Paneth cell defect in Japanese Crohn’s disease patients

BACKGROUND. Morphological patterns of Paneth cells are a prognostic biomarker in Western Crohn’s disease (CD) patients, and are associated with autophagy-associated ATG16L1 and NOD2 variants. We hypothesized that genetic determinants of Paneth cell phenotype in other ethnic CD cohorts are distinct b...

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發表在:JCI Insight
Main Authors: Liu, Ta-Chiang, Naito, Takeo, Liu, Zhenqiu, VanDussen, Kelli L., Haritunians, Talin, Li, Dalin, Endo, Katsuya, Kawai, Yosuke, Nagasaki, Masao, Kinouchi, Yoshitaka, McGovern, Dermot P.B., Shimosegawa, Tooru, Kakuta, Yoichi, Stappenbeck, Thaddeus S.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2017
主題:
Clinical Medicine
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358495/
https://ncbi.nlm.nih.gov/pubmed/28352666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.91917
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