TSG-6 Downregulates IFN-Alpha and TNF-Alpha Expression by Suppressing IRF7 Phosphorylation in Human Plasmacytoid Dendritic Cells

Proinflammatory cytokines such as TNF-α and type I interferons (IFN) are pathogenic signatures of systemic lupus erythematosus, and plasmacytoid dendritic cells (pDCs) play a major role by predominantly producing IFN-α. Given the rise of importance in identifying tumor necrosis stimulated gene 6 (TS...

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Vydáno v:Mediators Inflamm
Hlavní autoři: Kui, L., Chan, G. C., Lee, P. P. W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358455/
https://ncbi.nlm.nih.gov/pubmed/28367002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/7462945
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