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Simultaneous quantitation of abiraterone, enzalutamide, N-desmethyl enzalutamide, and bicalutamide in human plasma by LC-MS/MS

Inhibiting the androgen receptor (AR) pathway is an important clinical strategy in metastatic prostate cancer. Novel agents including abiraterone acetate and enzalutamide have been shown to prolong life in men with metastatic, castration-resistant prostate cancer (mCRPC). To evaluate the pharmacokin...

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Detalhes bibliográficos
Publicado no:J Pharm Biomed Anal
Main Authors: Kim, Kyu-pyo, Parise, Robert A., Holleran, Julianne L., Lewis, Lionel D., Appleman, Leonard, van Erp, Nielka, Morris, Michael J., Beumer, Jan H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357460/
https://ncbi.nlm.nih.gov/pubmed/28219796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2017.02.018
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