Analytical challenges in quantifying abiraterone with LC-MS/MS in human plasma

A method was developed and validated to quantify abiraterone in human plasma. During assay development several analytical challenges were encountered: limited stability in patient samples, adsorption to glass, co-elution with metabolites, and carry-over issues. Limited stability (2h) was found for a...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Biomed Chromatogr
Main Authors: Benoist, Guillemette E., van der Meulen, Eric, Lubberman, Floor J. E., Gerritsen, Winald R., Smilde, Tineke J., Schalken, Jack A., Beumer, Jan H., Burger, David M., van Erp, Nielka P.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6114173/
https://ncbi.nlm.nih.gov/pubmed/28370076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bmc.3986
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares