Polymorphisms in the multidrug-resistance 1 gene related to glucocorticoid response in rheumatoid arthritis treatment

A substantial proportion of rheumatoid arthritis (RA)-patients experience an insufficient response to glucocorticoids, an important therapeutic agent in RA. The multidrug-resistance 1 (MDR1) gene product P-glycoprotein (P-gp) is an efflux pump that actively transports substrates, such as glucocortic...

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Bibliographic Details
Published in:Rheumatol Int
Main Authors: Cuppen, Bart V. J., Pardali, Katerina, Kraan, Maarten C., Marijnissen, Anne C. A., Yrlid, Linda, Olsson, Marita, Bijlsma, Johannes W. J., Lafeber, Floris P. J. G., Fritsch-Stork, Ruth D. E.
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2017
Subjects:
Genes and Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357283/
https://ncbi.nlm.nih.gov/pubmed/28132103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00296-017-3653-1
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