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Evolutionary gain of alanine mischarging to non-cognate tRNAs with a G4:U69 base pair

Fidelity of translation, which is predominately dictated by the accuracy of aminoacyl-tRNA synthetases in pairing amino acids with correct tRNAs, is of central importance in biology. Yet, deliberate modifications of translational fidelity can be beneficial. Here we found human and not E. coli AlaRS...

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Detalles Bibliográficos
Publicado en:J Am Chem Soc
Main Authors: Sun, Litao, Gomes, Ana Cristina, He, Weiwei, Zhou, Huihao, Wang, Xiaoyun, Pan, David W., Schimmel, Paul, Pan, Tao, Yang, Xiang-Lei
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356932/
https://ncbi.nlm.nih.gov/pubmed/27622773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b07121
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