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Nonsense suppression by near-cognate tRNAs employs alternative base pairing at codon positions 1 and 3
Premature termination codons (PTCs) in an mRNA ORF inactivate gene function by causing production of a truncated protein and destabilization of the mRNA. Readthrough of a PTC allows ribosomal A-site insertion of a near-cognate tRNA, leading to synthesis of a full-length protein from otherwise defect...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4364220/ https://ncbi.nlm.nih.gov/pubmed/25733896 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424127112 |
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