Repurposing tRNAs for nonsense suppression

Three stop codons (UAA, UAG and UGA) terminate protein synthesis and are almost exclusively recognized by release factors. Here, we design de novo transfer RNAs (tRNAs) that efficiently decode UGA stop codons in Escherichia coli. The tRNA designs harness various functionally conserved aspects of sen...

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Publicado en:Nat Commun
Main Authors: Albers, Suki, Beckert, Bertrand, Matthies, Marco C., Mandava, Chandra Sekhar, Schuster, Raphael, Seuring, Carolin, Riedner, Maria, Sanyal, Suparna, Torda, Andrew E., Wilson, Daniel N., Ignatova, Zoya
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8219837/
https://ncbi.nlm.nih.gov/pubmed/34158503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24076-x
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