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Therapeutic promise of engineered nonsense suppressor tRNAs
Nonsense mutations change an amino acid codon to a premature termination codon (PTC) generally through a single‐nucleotide substitution. The generation of a PTC results in a defective truncated protein and often in severe forms of disease. Because of the exceedingly high prevalence of nonsense‐assoc...
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| Publicado no: | Wiley Interdiscip Rev RNA |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley & Sons, Inc.
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8244042/ https://ncbi.nlm.nih.gov/pubmed/33567469 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/wrna.1641 |
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