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Therapeutic promise of engineered nonsense suppressor tRNAs

Nonsense mutations change an amino acid codon to a premature termination codon (PTC) generally through a single‐nucleotide substitution. The generation of a PTC results in a defective truncated protein and often in severe forms of disease. Because of the exceedingly high prevalence of nonsense‐assoc...

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Detalles Bibliográficos
Publicado en:Wiley Interdiscip Rev RNA
Autores principales: Porter, Joseph J., Heil, Christina S., Lueck, John D.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley & Sons, Inc. 2021
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8244042/
https://ncbi.nlm.nih.gov/pubmed/33567469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/wrna.1641
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