Pazopanib, a novel multi-kinase inhibitor, shows potent antitumor activity in colon cancer through PUMA-mediated apoptosis

Colon cancer is still the third most common cancer which has a high mortality but low five-year survival rate. Novel tyrosine kinase inhibitors (TKI) such as pazopanib become effective antineoplastic agents that show promising clinical activity in a variety of carcinoma, including colon cancer. Howe...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Zhang, Lingling, Wang, Huanan, Li, Wei, Zhong, Juchang, Yu, Rongcheng, Huang, Xinfeng, Wang, Honghui, Tan, Zhikai, Wang, Jiangang, Zhang, Yingjie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356882/
https://ncbi.nlm.nih.gov/pubmed/27924057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13753
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