HIC1 (hypermethylated in cancer 1) SUMOylation is dispensable for DNA repair but is essential for the apoptotic DNA damage response (DDR) to irreparable DNA double-strand breaks (DSBs)

The tumor suppressor gene HIC1 (Hypermethylated In Cancer 1) encodes a transcriptional repressor mediating the p53-dependent apoptotic response to irreparable DNA double-strand breaks (DSBs) through direct transcriptional repression of SIRT1. HIC1 is also essential for DSB repair as silencing of end...

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Publicado en:Oncotarget
Autores principales: Paget, Sonia, Dubuissez, Marion, Dehennaut, Vanessa, Nassour, Joe, Harmon, Brennan T., Spruyt, Nathalie, Loison, Ingrid, Abbadie, Corinne, Rood, Brian R., Leprince, Dominique
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356852/
https://ncbi.nlm.nih.gov/pubmed/27935866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13807
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