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Identification of an HSP90 modulated multi-step process for ERBB2 degradation in breast cancer cells
The receptor tyrosine kinase ERBB2 interacts with HSP90 and is overexpressed in aggressive breast cancers. Therapeutic HSP90 inhibitors, i.e. Geldanamycin (GA), target ERBB2 to degradation. We have previously shown that HSP90 is responsible for the missorting of recycling ERBB2 to degradation compar...
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| Publié dans: | Oncotarget |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Impact Journals LLC
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5356745/ https://ncbi.nlm.nih.gov/pubmed/27863425 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13392 |
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