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Repair of 3-methylthymine and 1-methylguanine lesions by bacterial and human AlkB proteins

The Escherichia coli AlkB protein repairs 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) lesions in DNA and RNA by oxidative demethylation, a reaction requiring ferrous iron and 2-oxoglutarate as cofactor and co-substrate, respectively. Here, we have studied the activity of AlkB proteins on 3-...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteur principal: Falnes, Pål Ø.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2004
Sujets:
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC535673/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15576352/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkh964
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