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Repair of 3-methylthymine and 1-methylguanine lesions by bacterial and human AlkB proteins
The Escherichia coli AlkB protein repairs 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) lesions in DNA and RNA by oxidative demethylation, a reaction requiring ferrous iron and 2-oxoglutarate as cofactor and co-substrate, respectively. Here, we have studied the activity of AlkB proteins on 3-...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2004
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC535673/ https://ncbi.nlm.nih.gov/pubmed/15576352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh964 |
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