IL-37 suppresses hepatocellular carcinoma growth by converting pSmad3 signaling from JNK/pSmad3L/c-Myc oncogenic signaling to pSmad3C/P21 tumor-suppressive signaling

IL-37 has been characterized as a fundamental inhibitor of innate immunity and a tumor suppressor in several cancers. However, the molecular mechanism of IL-37 in hepatocellular carcinoma (HCC) is largely unclear. In this study we found IL-37 expression was down-regulated in human HCC tissues and ce...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Liu, Rui, Tang, Chengyong, Shen, Ai, Luo, Huating, Wei, Xufu, Zheng, Daofeng, Sun, Chao, Li, Zhongtang, Zhu, Di, Li, Tingting, Wu, Zhongjun
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2016
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356721/
https://ncbi.nlm.nih.gov/pubmed/27835881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13196
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