Mucin1 shifts Smad3 signaling from the tumor-suppressive pSmad3C/p21(WAF1) pathway to the oncogenic pSmad3L/c-Myc pathway by activating JNK in human hepatocellular carcinoma cells

Mucin1 (MUC1) is a transmembrane glycoprotein that acts as an oncogene in human hepatic tumorigenesis. Hepatocellular carcinoma (HCC) cells often gain advantage by reducing the tumor-suppressive activity of transforming growth factor beta (TGF-β) together with stimulation of its oncogenic activity a...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Li, Qiongshu, Liu, Guomu, Yuan, Hongyan, Wang, Juan, Guo, Yingying, Chen, Tanxiu, Zhai, Ruiping, Shao, Dan, Ni, Weihua, Tai, Guixiang
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414187/
https://ncbi.nlm.nih.gov/pubmed/25714018
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