Diisopropylamine dichloroacetate enhances radiosensitization in esophageal squamous cell carcinoma by increasing mitochondria-derived reactive oxygen species levels

Radiotherapy is generally applied in the treatment of esophageal squamous cell carcinoma (ESCC). However, the radioresistance of ESCC still remains an obstacle for the curative effect of this treatment. We hypothesized that diisopropylamine dichloroacetate (DADA), an inhibitor of pyruvate dehydrogen...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Dong, Gaochao, Chen, Qiang, Jiang, Feng, Yu, Decai, Mao, Qixing, Xia, Wenjie, Shi, Run, Wang, Jie, Xu, Lin
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356547/
https://ncbi.nlm.nih.gov/pubmed/27626688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11906
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