Diisopropylamine dichloroacetate enhances radiosensitization in esophageal squamous cell carcinoma by increasing mitochondria-derived reactive oxygen species levels

Radiotherapy is generally applied in the treatment of esophageal squamous cell carcinoma (ESCC). However, the radioresistance of ESCC still remains an obstacle for the curative effect of this treatment. We hypothesized that diisopropylamine dichloroacetate (DADA), an inhibitor of pyruvate dehydrogen...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Dong, Gaochao, Chen, Qiang, Jiang, Feng, Yu, Decai, Mao, Qixing, Xia, Wenjie, Shi, Run, Wang, Jie, Xu, Lin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356547/
https://ncbi.nlm.nih.gov/pubmed/27626688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11906
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