Diisopropylamine dichloroacetate enhances radiosensitization in esophageal squamous cell carcinoma by increasing mitochondria-derived reactive oxygen species levels

Radiotherapy is generally applied in the treatment of esophageal squamous cell carcinoma (ESCC). However, the radioresistance of ESCC still remains an obstacle for the curative effect of this treatment. We hypothesized that diisopropylamine dichloroacetate (DADA), an inhibitor of pyruvate dehydrogen...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Dong, Gaochao, Chen, Qiang, Jiang, Feng, Yu, Decai, Mao, Qixing, Xia, Wenjie, Shi, Run, Wang, Jie, Xu, Lin
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356547/
https://ncbi.nlm.nih.gov/pubmed/27626688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11906
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