Genetic inhibition of autophagy promotes p53 loss-of-heterozygosity and tumorigenesis

Autophagy is an evolutionarily conserved lysosomal degradation pathway that plays an essential role in enabling eukaryotic organisms to adapt to nutrient deprivation and other forms of environmental stress. In metazoan organisms, autophagy is essential for differentiation and normal development; how...

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Udgivet i:Oncotarget
Main Authors: Lee, Eunmyong, Wei, Yongjie, Zou, Zhongju, Tucker, Kathryn, Rakheja, Dinesh, Levine, Beth, Amatruda, James F.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper: Autophagy and Cell Death
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356529/
https://ncbi.nlm.nih.gov/pubmed/27655644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12084
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