Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia

Drug sensitivity and resistance testing on diagnostic leukemia samples should provide important functional information to guide actionable target and biomarker discovery. We provide proof of concept data by profiling 60 drugs on 68 acute lymphoblastic leukemia (ALL) samples mostly from resistant dis...

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Veröffentlicht in:Blood
Hauptverfasser: Frismantas, Viktoras, Dobay, Maria Pamela, Rinaldi, Anna, Tchinda, Joelle, Dunn, Samuel H., Kunz, Joachim, Richter-Pechanska, Paulina, Marovca, Blerim, Pail, Orrin, Jenni, Silvia, Diaz-Flores, Ernesto, Chang, Bill H., Brown, Timothy J., Collins, Robert H., Uhrig, Sebastian, Balasubramanian, Gnana P., Bandapalli, Obul R., Higi, Salome, Eugster, Sabrina, Voegeli, Pamela, Delorenzi, Mauro, Cario, Gunnar, Loh, Mignon L., Schrappe, Martin, Stanulla, Martin, Kulozik, Andreas E., Muckenthaler, Martina U., Saha, Vaskar, Irving, Julie A., Meisel, Roland, Radimerski, Thomas, Von Stackelberg, Arend, Eckert, Cornelia, Tyner, Jeffrey W., Horvath, Peter, Bornhauser, Beat C., Bourquin, Jean-Pierre
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2017
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356455/
https://ncbi.nlm.nih.gov/pubmed/28122742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-09-738070
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