A Study on CYP2C19 and CYP2D6 Polymorphic Effects on Pharmacokinetics and Pharmacodynamics of Amitriptyline in Healthy Koreans

We performed a double‐blinded, genotype‐based stratification study to explore the pharmacokinetics and pharmacodynamics of amitriptyline according to CYP2C19 and CYP2D6 genotype in Korean subjects. Twenty‐four healthy adults were grouped by genotype of CYP2C19 and CYP2D6. After a single dose of 25 m...

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Publicado en:Clin Transl Sci
Autores principales: Ryu, S, Park, S, Lee, JH, Kim, YR, Na, HS, Lim, HS, Choi, HY, Hwang, IY, Lee, JG, Park, ZW, Oh, WY, Kim, JM, Choi, SE
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355968/
https://ncbi.nlm.nih.gov/pubmed/28296334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12451
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