Influence of CYP2D6 Polymorphism on the Pharmacokinetic/Pharmacodynamic Characteristics of Carvedilol in Healthy Korean Volunteers

BACKGROUND: Carvedilol is commonly used to treat hypertension as a β- and α(1)-adrenoreceptor blocker, but it is metabolized by CYP2D6, and CYP2D6(*)10 allele is dominant in Asian population. The objective of this study was to assess the influence of CYP2D6 polymorphisms on the pharmacokinetic (PK)...

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Detalhes bibliográficos
Publicado no:J Korean Med Sci
Main Authors: Jung, Eben, Ryu, Sunae, Park, Zewon, Lee, Jong-Gu, Yi, Jung-Yeon, Seo, Doo Won, Lee, Juhyun, Jeong, Ho-Sang, Kim, Jeong Mi, Oh, Woo-Yong
Formato: Artigo
Idioma:Inglês
Publicado em: The Korean Academy of Medical Sciences 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021360/
https://ncbi.nlm.nih.gov/pubmed/29962926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3346/jkms.2018.33.e182
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