A Study on CYP2C19 and CYP2D6 Polymorphic Effects on Pharmacokinetics and Pharmacodynamics of Amitriptyline in Healthy Koreans

We performed a double‐blinded, genotype‐based stratification study to explore the pharmacokinetics and pharmacodynamics of amitriptyline according to CYP2C19 and CYP2D6 genotype in Korean subjects. Twenty‐four healthy adults were grouped by genotype of CYP2C19 and CYP2D6. After a single dose of 25 m...

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Detalhes bibliográficos
Publicado no:Clin Transl Sci
Main Authors: Ryu, S, Park, S, Lee, JH, Kim, YR, Na, HS, Lim, HS, Choi, HY, Hwang, IY, Lee, JG, Park, ZW, Oh, WY, Kim, JM, Choi, SE
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355968/
https://ncbi.nlm.nih.gov/pubmed/28296334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12451
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