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OleD Loki as a Catalyst for Tertiary Amine and Hydroxamate Glycosylation

We describe the ability of an engineered glycosyltransferase (OleD Loki) to catalyze the N-glycosylation of tertiary-amine-containing drugs and trichostatin hydroxamate glycosyl ester formation. As such, this study highlights the first bacterial model catalyst for tertiary-amine N-glycosylation and...

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Pubblicato in:Chembiochem
Autori principali: Hughes, Ryan R., Shaaban, Khaled A., Zhang, Jianjun, Cao, Hongnan, Phillips, George N., Thorson, Jon S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355705/
https://ncbi.nlm.nih.gov/pubmed/28067448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201600676
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