OleD Loki as a Catalyst for Hydroxamate Glycosylation

Herein we describe the ability of the permissive glycosyltransferase (GT) OleD Loki to convert a diverse set of > 15 histone deacetylase (HDAC) inhibitors (HDACis) into their corresponding hydroxamate glycosyl esters. Representative glycosyl esters were subsequently evaluated in assays for cancer...

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Pubblicato in:Chembiochem
Autori principali: Hughes, Ryan R., Shaaban, Khaled A., Ponomareva, Larissa V., Horn, Jamie, Zhang, Chunhui, Zhan, Chang-Guo, Voss, S. Randal, Leggas, Markos, Thorson, Jon S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7124993/
https://ncbi.nlm.nih.gov/pubmed/31621997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201900601
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