In Vitro Modeling of Blood-Brain Barrier with Human iPSC-Derived Endothelial Cells, Pericytes, Neurons, and Astrocytes via Notch Signaling

The blood-brain barrier (BBB) is composed of four cell populations, brain endothelial cells (BECs), pericytes, neurons, and astrocytes. Its role is to precisely regulate the microenvironment of the brain through selective substance crossing. Here we generated an in vitro model of the BBB by differen...

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Veröffentlicht in:Stem Cell Reports
Hauptverfasser: Yamamizu, Kohei, Iwasaki, Mio, Takakubo, Hitomi, Sakamoto, Takumi, Ikuno, Takeshi, Miyoshi, Mami, Kondo, Takayuki, Nakao, Yoichi, Nakagawa, Masato, Inoue, Haruhisa, Yamashita, Jun K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355679/
https://ncbi.nlm.nih.gov/pubmed/28238797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.01.023
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