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In Vitro Modeling of Blood-Brain Barrier with Human iPSC-Derived Endothelial Cells, Pericytes, Neurons, and Astrocytes via Notch Signaling

The blood-brain barrier (BBB) is composed of four cell populations, brain endothelial cells (BECs), pericytes, neurons, and astrocytes. Its role is to precisely regulate the microenvironment of the brain through selective substance crossing. Here we generated an in vitro model of the BBB by differen...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Yamamizu, Kohei, Iwasaki, Mio, Takakubo, Hitomi, Sakamoto, Takumi, Ikuno, Takeshi, Miyoshi, Mami, Kondo, Takayuki, Nakao, Yoichi, Nakagawa, Masato, Inoue, Haruhisa, Yamashita, Jun K.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355679/
https://ncbi.nlm.nih.gov/pubmed/28238797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.01.023
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