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NLS-RARα modulates acute promyelocytic leukemia NB4 cell proliferation and differentiation via the PI3K/AKT pathway
In patients with acute promyelocytic leukemia (APL), ~98% express the promyelocytic leukemia (PML)-retinoic acid receptor α (RARα) fusion protein. Previous studies have shown that, in primary leukemia cells of patients with APL, the cleavage of PML-RARα by neutrophil elastase is important for its ab...
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| Publicado no: | Mol Med Rep |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
D.A. Spandidos
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5355661/ https://ncbi.nlm.nih.gov/pubmed/27840989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2016.5932 |
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