Hierarchical and Redundant Roles of Activating FcγRs in Protection against Influenza Disease by M2e-Specific IgG1 and IgG2a Antibodies

The ectodomain of matrix protein 2 is a universal influenza A virus vaccine candidate that provides protection through antibody-dependent effector mechanisms. Here we compared the functional engagement of Fcγ receptor (FcγR) family members by two M2e-specific monoclonal antibodies (MAbs), MAb 37 (Ig...

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Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Van den Hoecke, Silvie, Ehrhardt, Katrin, Kolpe, Annasaheb, El Bakkouri, Karim, Deng, Lei, Grootaert, Hendrik, Schoonooghe, Steve, Smet, Anouk, Bentahir, Mostafa, Roose, Kenny, Schotsaert, Michael, Schepens, Bert, Callewaert, Nico, Nimmerjahn, Falk, Staeheli, Peter, Hengel, Hartmut, Saelens, Xavier
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2017
Sujets:
Pathogenesis and Immunity
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355615/
https://ncbi.nlm.nih.gov/pubmed/28077656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02500-16
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