Vaccination with EphA2-derived T cell-epitopes promotes immunity against both EphA2-expressing and EphA2-negative tumors

BACKGROUND: A novel tyrosine kinase receptor EphA2 is expressed at high levels in advanced and metastatic cancers. We examined whether vaccinations with synthetic mouse EphA2 (mEphA2)-derived peptides that serve as T cell epitopes could induce protective and therapeutic anti-tumor immunity. METHODS:...

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Hlavní autoři: Hatano, Manabu, Kuwashima, Naruo, Tatsumi, Tomohide, Dusak, Jill E, Nishimura, Fumihiko, Reilly, Karlyne M, Storkus, Walter J, Okada, Hideho
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2004
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC535538/
https://ncbi.nlm.nih.gov/pubmed/15563374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-2-40
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