Arg-Leu-Tyr-Glu tetrapeptide inhibits tumor progression by suppressing angiogenesis and vascular permeability via VEGF receptor-2 antagonism

The tetrapeptide Arg-Leu-Tyr-Glu (RLYE) is known to inhibit vascular endothelial growth factor-A (VEGF-A)-induced angiogenesis in vitro. Herein, we examined its underlying mechanism and antitumor activity associated with vascular remodeling. RLYE inhibited VEGF-A-induced angiogenesis in a mouse mode...

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Publicado en:Oncotarget
Autores principales: Baek, Yi-Yong, Lee, Dong-Keon, Kim, Joohwan, Kim, Ji-Hee, Park, Wonjin, Kim, Taesam, Han, Sanghwa, Jeoung, Dooil, You, Ji Chang, Lee, Hansoo, Won, Moo-Ho, Ha, Kwon-Soo, Kwon, Young-Guen, Kim, Young-Myeong
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355302/
https://ncbi.nlm.nih.gov/pubmed/28052029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14343
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