Arg-Leu-Tyr-Glu tetrapeptide inhibits tumor progression by suppressing angiogenesis and vascular permeability via VEGF receptor-2 antagonism

The tetrapeptide Arg-Leu-Tyr-Glu (RLYE) is known to inhibit vascular endothelial growth factor-A (VEGF-A)-induced angiogenesis in vitro. Herein, we examined its underlying mechanism and antitumor activity associated with vascular remodeling. RLYE inhibited VEGF-A-induced angiogenesis in a mouse mode...

Full description

Saved in:
Bibliographic Details
Published in:Oncotarget
Main Authors: Baek, Yi-Yong, Lee, Dong-Keon, Kim, Joohwan, Kim, Ji-Hee, Park, Wonjin, Kim, Taesam, Han, Sanghwa, Jeoung, Dooil, You, Ji Chang, Lee, Hansoo, Won, Moo-Ho, Ha, Kwon-Soo, Kwon, Young-Guen, Kim, Young-Myeong
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355302/
https://ncbi.nlm.nih.gov/pubmed/28052029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14343
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items