A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)- 1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell lines

Cardiac glycosides are well known in the treatment of cardiovascular diseases; however, their application as treatment option for cancer patients is under discussion. We showed that the cardiac glycoside digitoxin and its analog AMANTADIG can inhibit the growth of renal cell carcinoma (RCC) cell lin...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Nolte, Elke, Wach, Sven, Silva, Izabella Thais, Lukat, Sabine, Ekici, Arif B., Munkert, Jennifer, Müller-Uri, Frieder, Kreis, Wolfgang, Simões, Cláudia Maria Oliveira, Vera, Julio, Wullich, Bernd, Taubert, Helge, Lai, Xin
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355295/
https://ncbi.nlm.nih.gov/pubmed/28099931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14644
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