A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)- 1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell lines

Cardiac glycosides are well known in the treatment of cardiovascular diseases; however, their application as treatment option for cancer patients is under discussion. We showed that the cardiac glycoside digitoxin and its analog AMANTADIG can inhibit the growth of renal cell carcinoma (RCC) cell lin...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Nolte, Elke, Wach, Sven, Silva, Izabella Thais, Lukat, Sabine, Ekici, Arif B., Munkert, Jennifer, Müller-Uri, Frieder, Kreis, Wolfgang, Simões, Cláudia Maria Oliveira, Vera, Julio, Wullich, Bernd, Taubert, Helge, Lai, Xin
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2017
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355295/
https://ncbi.nlm.nih.gov/pubmed/28099931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14644
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