MET receptor variant R970C favors calpain-dependent generation of a fragment promoting epithelial cell scattering

The receptor tyrosine kinase MET and its ligand, the hepatocyte growth factor, are essential to embryonic development, whereas deregulation of MET signaling is associated with tumorigenesis leading to various cancers, including lung carcinoma. Mutations in the MET kinase domain lead to constitutive...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Montagne, Rémi, Baranzelli, Anne, Muharram, Ghaffar, Catherine, Leroy, Lesaffre, Marie, Vinchent, Audrey, Kherrouche, Zoulika, Werkmeister, Elisabeth, Cortot, Alexis B, Tulasne, David
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355264/
https://ncbi.nlm.nih.gov/pubmed/28061464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14499
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