MET receptor variant R970C favors calpain-dependent generation of a fragment promoting epithelial cell scattering

The receptor tyrosine kinase MET and its ligand, the hepatocyte growth factor, are essential to embryonic development, whereas deregulation of MET signaling is associated with tumorigenesis leading to various cancers, including lung carcinoma. Mutations in the MET kinase domain lead to constitutive...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Montagne, Rémi, Baranzelli, Anne, Muharram, Ghaffar, Catherine, Leroy, Lesaffre, Marie, Vinchent, Audrey, Kherrouche, Zoulika, Werkmeister, Elisabeth, Cortot, Alexis B, Tulasne, David
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2017
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355264/
https://ncbi.nlm.nih.gov/pubmed/28061464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14499
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