UV-induced proteolysis of RNA polymerase II is mediated by VCP/p97 segregase and timely orchestration by Cockayne syndrome B protein

RNA polymerase II (RNAPII) acts as a damage sensor for transcription-coupled nucleotide excision repair (TC-NER) and undergoes proteolytic clearance from damaged chromatin by the ubiquitin-proteasome system (UPS). Here, we report that Valosin-containing protein (VCP)/p97, a druggable oncotarget, is...

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Veröffentlicht in:Oncotarget
Hauptverfasser: He, Jinshan, Zhu, Qianzheng, Wani, Gulzar, Wani, Altaf A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355241/
https://ncbi.nlm.nih.gov/pubmed/28036256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14205
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