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FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors
-like tyrosine kinase-3 (FLT3) is a receptor tyrosine kinase that normally functions in hematopoietic cell survival, proliferation and differentiation. Constitutively activating mutations of FLT3 map predominately to the juxtamembrane domain (internal tandem duplications; ITD) or the activation loop...
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| Pubblicato in: | Oncotarget |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Impact Journals LLC
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5355235/ https://ncbi.nlm.nih.gov/pubmed/28077790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14539 |
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