FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors

-like tyrosine kinase-3 (FLT3) is a receptor tyrosine kinase that normally functions in hematopoietic cell survival, proliferation and differentiation. Constitutively activating mutations of FLT3 map predominately to the juxtamembrane domain (internal tandem duplications; ITD) or the activation loop...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Nguyen, Bao, Williams, Allen B., Young, David J., Ma, Hayley, Li, Li, Levis, Mark, Brown, Patrick, Small, Donald
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2017
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355235/
https://ncbi.nlm.nih.gov/pubmed/28077790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14539
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