MicroRNA-140 mediates RB tumor suppressor function to control stem cell-like activity through interleukin-6

We established an in vitro cell culture system to determine novel activities of the retinoblastoma (Rb) protein during tumor progression. Rb depletion in p53-null mouse-derived soft tissue sarcoma cells induced a spherogenic phenotype. Cells retrieved from Rb-depleted spheres exhibited slower prolif...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Yoshida, Akiyo, Kitajima, Shunsuke, Li, Fengkai, Cheng, Chaoyang, Takegami, Yujiro, Kohno, Susumu, Wan, Yuan Song, Hayashi, Naoyuki, Muranaka, Hayato, Nishimoto, Yuuki, Nagatani, Naoko, Nishiuchi, Takumi, Thai, Tran C, Suzuki, Sawako, Nakao, Shinji, Tanaka, Tomoaki, Hirose, Osamu, Barbie, David A., Takahashi, Chiaki
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355146/
https://ncbi.nlm.nih.gov/pubmed/28099924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14681
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