Clinically relevant HIF-1α-dependent metabolic reprogramming in oropharyngeal squamous cell carcinomas includes coordinated activation of CAIX and the miR-210/ISCU signaling axis, but not MCT1 and MCT4 upregulation

Metabolic reprogramming is a very heterogeneous phenomenon in cancer. It mostly consists on increased glycolysis, lactic acid formation and extracellular acidification. These events have been associated to increased activity of the hypoxia inducible factor, HIF-1α. This study aimed at defining the m...

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Podrobná bibliografie
Vydáno v:Oncotarget
Hlavní autoři: Sáenz-de-Santa-María, Inés, Bernardo-Castiñeira, Cristóbal, Secades, Pablo, Bernaldo-de-Quirós, Sandra, Rodrigo, Juan Pablo, Astudillo, Aurora, Chiara, María-Dolores
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355133/
https://ncbi.nlm.nih.gov/pubmed/28099149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14629
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