Clinically relevant HIF-1α-dependent metabolic reprogramming in oropharyngeal squamous cell carcinomas includes coordinated activation of CAIX and the miR-210/ISCU signaling axis, but not MCT1 and MCT4 upregulation

Metabolic reprogramming is a very heterogeneous phenomenon in cancer. It mostly consists on increased glycolysis, lactic acid formation and extracellular acidification. These events have been associated to increased activity of the hypoxia inducible factor, HIF-1α. This study aimed at defining the m...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Sáenz-de-Santa-María, Inés, Bernardo-Castiñeira, Cristóbal, Secades, Pablo, Bernaldo-de-Quirós, Sandra, Rodrigo, Juan Pablo, Astudillo, Aurora, Chiara, María-Dolores
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2017
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355133/
https://ncbi.nlm.nih.gov/pubmed/28099149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14629
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