Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1α, CAIX, LDH-5, GLUT-1, MCT1 and MCT4

BACKGROUND: The cellular response of malignant tumors to hypoxia is diverse. Several important endogenous metabolic markers are upregulated under hypoxic conditions. We examined the staining patterns and co-expression of HIF-1α, CAIX, LDH-5, GLUT-1, MCT1 and MCT4 with the exogenous hypoxic cell mark...

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Main Authors: Rademakers, Saskia E, Lok, Jasper, van der Kogel, Albert J, Bussink, Johan, Kaanders, Johannes HAM
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3115911/
https://ncbi.nlm.nih.gov/pubmed/21569415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-11-167
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