Melatonin Antagonizes Nickel-Induced Aerobic Glycolysis by Blocking ROS-Mediated HIF-1α/miR210/ISCU Axis Activation

Nickel and its compounds, which are well-documented carcinogens, induce the Warburg effect in normal cells by stabilizing hypoxia-inducible factor 1α (HIF-1α). Melatonin has shown diverse anticancer properties for its reactive oxygen species- (ROS-) scavenging ability. Our aim was to explore how mel...

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Publicat a:Oxid Med Cell Longev
Autors principals: He, Mindi, Zhou, Chao, Lu, Yonghui, Mao, Ling, Xi, Yu, Mei, Xiang, Wang, Xue, Zhang, Lei, Yu, Zhengping, Zhou, Zhou
Format: Artigo
Idioma:Inglês
Publicat: Hindawi 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7275958/
https://ncbi.nlm.nih.gov/pubmed/32566089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/5406284
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