Targeted delivery of chemotherapy using HSP90 inhibitor drug conjugates is highly active against pancreatic cancer models

The lack of effective treatment modalities is a major problem in pancreatic cancer (PCa), a devastating malignancy that is nearly universally driven by the “undruggable” KRAS and TP53 cancer genes. Poor tumor tissue penetration is the major source of resistance in pancreatic cancer where chemotherap...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Bobrov, Egor, Skobeleva, Natalia, Restifo, Diana, Beglyarova, Natalya, Cai, Kathy Q., Handorf, Elizabeth, Campbell, Kerry, Proia, David A., Khazak, Vladimir, Golemis, Erica A., Astsaturov, Igor
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354841/
https://ncbi.nlm.nih.gov/pubmed/27779106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12642
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