Screening of conditionally reprogrammed patient-derived carcinoma cells identifies ERCC3-MYC interactions as a target in pancreatic cancer

PURPOSE: Even when diagnosed prior to metastasis, pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with almost 90% lethality, emphasizing the need for new therapies optimally targeting the tumors of individual patients. EXPERIMENTAL DESIGN: We first developed a panel of new physio...

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Pubblicato in:Clin Cancer Res
Autori principali: Beglyarova, Natalya, Banina, Eugenia, Zhou, Yan, Mukhamadeeva, Ramilia, Andrianov, Grigorii, Bobrov, Egor, Lysenko, Elena, Skobeleva, Natalya, Gabitova, Linara, Restifo, Diana, Pressman, Max, Serebriiskii, Ilya G., Hoffman, John P., Paz, Keren, Behrens, Diana, Khazak, Vladimir, Jablonski, Sandra A., Golemis, Erica A., Weiner, Louis M., Astsaturov, Igor
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161635/
https://ncbi.nlm.nih.gov/pubmed/27384421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-0149
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