Antagonism of Interleukin-17A ameliorates experimental hepatic fibrosis by restoring the IL-10/STAT3-suppressed autophagy in hepatocytes

Interleukin-17A has been identified as a driver of hepatic stellate cell activation and plays a critical role in the pathogenesis of hepatic fibrosis. However, the underlining fibrosis-promoting mechanism of IL-17A is far from understood. Here we aimed to define whether hepatocytes directly respond...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Zhang, Xiao-Wei, Mi, Su, Li, Zhe, Zhou, Ji-Chao, Xie, Jing, Hua, Fang, Li, Ke, Cui, Bing, Lv, Xiao-Xi, Yu, Jiao-Jiao, Hu, Zhuo-Wei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354781/
https://ncbi.nlm.nih.gov/pubmed/28039485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14266
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