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17-hydroxy wortmannin restores TRAIL’s response by ameliorating increased beclin 1 level and autophagy function in TRAIL-resistant colon cancer cells
Targeting of extrinsic apoptosis pathway by TNF related apoptosis-inducing ligand (TRAIL) is an attractive approach for cancer therapy. However, two TRAIL drug candidates failed in clinical trials due to lack of efficacy. We identified 17-hydroxy wortmannin (17-HW) in a drug repurposing screen that...
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| Udgivet i: | Mol Cancer Ther |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6606373/ https://ncbi.nlm.nih.gov/pubmed/31092562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-1241 |
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