Identification of mTOR as a primary resistance factor of the IAP antagonist AT406 in hepatocellular carcinoma cells

Dysregulation of inhibitor of apoptosis (IAP) proteins (IAPs) in hepatocellular carcinoma (HCC) is often associated with poor prognosis. Here we showed that AT406, an IAP antagonist, was cytotoxic and pro-apoptotic to both established (HepG2, SMMC-7721 lines) and primary HCC cells. Activation of mTO...

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Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Zhen, Mao-Chuan, Wang, Fu-Qiang, Wu, Shao-Feng, Zhao, Yi-Lin, Liu, Ping-Guo, Yin, Zhen-Yu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2016
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354745/
https://ncbi.nlm.nih.gov/pubmed/28036295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14326
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