Identification of mTOR as a primary resistance factor of the IAP antagonist AT406 in hepatocellular carcinoma cells

Dysregulation of inhibitor of apoptosis (IAP) proteins (IAPs) in hepatocellular carcinoma (HCC) is often associated with poor prognosis. Here we showed that AT406, an IAP antagonist, was cytotoxic and pro-apoptotic to both established (HepG2, SMMC-7721 lines) and primary HCC cells. Activation of mTO...

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Udgivet i:Oncotarget
Main Authors: Zhen, Mao-Chuan, Wang, Fu-Qiang, Wu, Shao-Feng, Zhao, Yi-Lin, Liu, Ping-Guo, Yin, Zhen-Yu
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354745/
https://ncbi.nlm.nih.gov/pubmed/28036295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14326
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