Mesothelin-targeted immunotoxin RG7787 has synergistic anti-tumor activity when combined with taxanes

Recombinant immunotoxins (RITs) are antibody-based therapeutics that carry a toxin payload. The RG7787 RIT targets the cancer antigen mesothelin to deliver a recombinantly-engineered, reduced immunogenicity variant of Pseudomonas exotoxin A (PE) to the cytosol where it inhibits protein synthesis. He...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Kolyvas, Emily, Rudloff, Michael, Poruchynsky, Marianne, Landsman, Rebekah, Hollevoet, Kevin, Venzon, David, Alewine, Christine
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354724/
https://ncbi.nlm.nih.gov/pubmed/27999204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13984
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