Protein Synthesis Inhibition Activity of Mesothelin Targeting Immunotoxin LMB-100 Decreases Concentrations of Oncogenic Signaling Molecules and Secreted Growth Factors

LMB-100 is a mesothelin-targeted recombinant immunotoxin (iTox) that carries a modified Pseuodomonas exotoxin A (PE) payload. PE kills cells by inhibiting synthesis of new proteins. We found that treatment of pancreatic cancer cells with LMB-100 for 24–48 h did not change total protein level despite...

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Publicado en:Toxins (Basel)
Autores principales: El-Behaedi, Salma, Landsman, Rebekah, Rudloff, Michael, Kolyvas, Emily, Albalawy, Rakan, Zhang, Xianyu, Bera, Tapan, Collins, Keith, Kozlov, Serguei, Alewine, Christine
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6267581/
https://ncbi.nlm.nih.gov/pubmed/30384408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins10110447
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