Targeted activation of AMPK by GSK621 ameliorates H(2)O(2)-induced damages in osteoblasts

GSK621 is a novel AMP-activated protein kinase (AMPK) activator. This study tested its potential cytoprotective effect in hydrogen peroxide (H(2)O(2))-treated osteoblasts. In cultured MC3T3-E1 osteoblastic cells and primary murine osteoblasts, GSK621 significantly attenuated H(2)O(2)-induced cell de...

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Udgivet i:Oncotarget
Main Authors: Liu, Weidong, Mao, Li, Ji, Feng, Chen, Fengli, Hao, Yuedong, Liu, Gang
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354679/
https://ncbi.nlm.nih.gov/pubmed/28060740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14454
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